Volume 16, Issue 3 (9-2025)
Res Anim Prod 2025, 16(3): 95-105 |
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Hajkhodadadi I, Ghasemi H A, bahrami M R. (2025). Evaluation of Using Savofen© on Performance and Some Blood Biochemical Parameters of Broilers in Stress Condition with Dexamethasone. Res Anim Prod. 16(3), 95-105. doi:10.61882/rap.2025.1443
URL: http://rap.sanru.ac.ir/article-1-1443-en.html
URL: http://rap.sanru.ac.ir/article-1-1443-en.html
1- Department of Animal Science, Arak University, Arak, Iran
Abstract: (1019 Views)
Extended Abstract
Background: In recent decades, the poultry farming industry has used antibiotics for prevention, maintaining health, stimulating growth, and improving production. Due to the increase in bacterial resistance and their retention in the tissue and secondary effects, the use of antibiotics as growth promotors in the livestock and poultry industry has caused concerns. The indiscriminate use of antibiotics has caused concerns in the livestock and poultry industry due to the increase in bacterial resistance, their retention in tissues, and the occurrence of dangerous diseases, such as cancer. The unauthorized use of these compounds in poultry feed and failure to observe the appropriate time interval for removal and disposal from the carcass to the consumer market cause dangerous diseases, such as cancer, as well as sensitivity, secondary infections, and increase the antibiotic resistance of microorganisms in consumers. Therefore, the concern of researchers is to use suitable and harmless alternatives instead of antibiotics in poultry diets. Recently, derivatives of medicinal plants (phytobiotics), such as medicinal plants, essential oils, and herbal seasonings, have been introduced as alternatives. The characteristics of medicinal plants include desirable therapeutic properties, stimulation of food consumption, and antimicrobial and antioxidant activity. Previous studies have shown that the use of dexamethasone mimics the adverse effects of increased corticosterone in broiler chickens and causes an increase in free radicals and induction of oxidative stress. Research findings have confirmed that plant essential oils significantly help the development of the poultry's immune system and improve their performance in real or induced stressful conditions.
Methods: This experiment was conducted to investigate the effect of the Savofen© commercial product on performance, carcass trait yields, some blood metabolites, and antioxidant enzymes in broiler chickens under stress induction conditions by dexamethasone. Experimental treatments included 1) control treatment (positive control), 2) negative control treatment (treatment under stress by dexamethasone), 3) negative control with 200 mg of Savofen©, and 4) negative control with 400 mg of Savofen©. Body weight, feed intake, and feed conversion ratio (FCR) were measured at the end of each experimental period. A total number of 400 one-day-old male broiler chicks (Ross 308) were used for 42 days to investigate the effect of different Savofen supplementation levels in a corn-soybean meal-based diet on performance, carcass traits, blood biochemistry, and antioxidant status of broilers reared under heat stress conditions. The basic diet of experimental treatments was adjusted based on the needs presented in the Ross 308 breeding management guide by UFFDA software. All experimental diets were the same in energy, protein, and other nutrient contents. Feed consumption and body weight were measured at the end of each initial, growth, and final periods. Daily weight gain and FCR were also calculated during the experiment. Glucose, protein, triglyceride, cholesterol, HDL cholesterol, and LDL cholesterol in the serum, etc., were measured using Pars Azmoun Enzyme Kits and a spectrophotometer (model Ce1010, England).
Results: At the end of the period, the body weight of the positive control treatment and the treatment containing 0.4 Savofen with dexamethasone stress showed similar performance, and were significant compared to the negative control treatment (p < 0.05). The average body weight gain at the end of the period between positive control treatments and treatment with 0.4 Savofen with dexamethasone stress had the same performance, and there was no significant difference (p > 0.05). The negative control treatment and 0.2 Savofen treatment with dexamethasone stress also had the same performance (p > 0.05), but a significant difference was observed compared to the other treatments (p < 0.05). None of the blood traits, including blood glucose, triglyceride, cholesterol, HDL, LDL, VLDL, and glutamine, had significant differences (p > 0.05). Both aspartate aminotransferase and alanine aminotransferase enzymes were significantly different in the negative control treatment compared to the other treatments (p < 0.05). The two enzymes, superoxide dismutase and glutathione peroxidase, had significant differences in the positive control treatment compared to the other treatments (p < 0.05). In the malondialdehyde component, the positive control treatment of 0.2 Savofen with stress induction and dexamethasone had similar performance, but they were significantly different compared to the 0.4 Savofen treatment with stress induction and dexamethasone (p < 0.05). The total antioxidant capacity was also significantly different in the negative control treatment compared to the other treatments (p < 0.05). The components of corticosterone and triiodothyronine in the negative control treatment were significantly different from the other treatments (p < 0.05). On the other hand, there were no significant differences between the treatments in the tetraidothyronine component. The ratio of triiodothyronine to tetraiodothyronine was the same in all treatments and had a significant difference compared to the positive control treatment (p < 0.05).
Conclusion: In general, the 0.4 Savofen treatment under the stress conditions showed its positive performance during the stress conditions, and its performance was similar to the positive control treatment in most of the traits. Therefore, it can be concluded that this supplement can be used to improve stressful situations in rearing broiler chickens.
Background: In recent decades, the poultry farming industry has used antibiotics for prevention, maintaining health, stimulating growth, and improving production. Due to the increase in bacterial resistance and their retention in the tissue and secondary effects, the use of antibiotics as growth promotors in the livestock and poultry industry has caused concerns. The indiscriminate use of antibiotics has caused concerns in the livestock and poultry industry due to the increase in bacterial resistance, their retention in tissues, and the occurrence of dangerous diseases, such as cancer. The unauthorized use of these compounds in poultry feed and failure to observe the appropriate time interval for removal and disposal from the carcass to the consumer market cause dangerous diseases, such as cancer, as well as sensitivity, secondary infections, and increase the antibiotic resistance of microorganisms in consumers. Therefore, the concern of researchers is to use suitable and harmless alternatives instead of antibiotics in poultry diets. Recently, derivatives of medicinal plants (phytobiotics), such as medicinal plants, essential oils, and herbal seasonings, have been introduced as alternatives. The characteristics of medicinal plants include desirable therapeutic properties, stimulation of food consumption, and antimicrobial and antioxidant activity. Previous studies have shown that the use of dexamethasone mimics the adverse effects of increased corticosterone in broiler chickens and causes an increase in free radicals and induction of oxidative stress. Research findings have confirmed that plant essential oils significantly help the development of the poultry's immune system and improve their performance in real or induced stressful conditions.
Methods: This experiment was conducted to investigate the effect of the Savofen© commercial product on performance, carcass trait yields, some blood metabolites, and antioxidant enzymes in broiler chickens under stress induction conditions by dexamethasone. Experimental treatments included 1) control treatment (positive control), 2) negative control treatment (treatment under stress by dexamethasone), 3) negative control with 200 mg of Savofen©, and 4) negative control with 400 mg of Savofen©. Body weight, feed intake, and feed conversion ratio (FCR) were measured at the end of each experimental period. A total number of 400 one-day-old male broiler chicks (Ross 308) were used for 42 days to investigate the effect of different Savofen supplementation levels in a corn-soybean meal-based diet on performance, carcass traits, blood biochemistry, and antioxidant status of broilers reared under heat stress conditions. The basic diet of experimental treatments was adjusted based on the needs presented in the Ross 308 breeding management guide by UFFDA software. All experimental diets were the same in energy, protein, and other nutrient contents. Feed consumption and body weight were measured at the end of each initial, growth, and final periods. Daily weight gain and FCR were also calculated during the experiment. Glucose, protein, triglyceride, cholesterol, HDL cholesterol, and LDL cholesterol in the serum, etc., were measured using Pars Azmoun Enzyme Kits and a spectrophotometer (model Ce1010, England).
Results: At the end of the period, the body weight of the positive control treatment and the treatment containing 0.4 Savofen with dexamethasone stress showed similar performance, and were significant compared to the negative control treatment (p < 0.05). The average body weight gain at the end of the period between positive control treatments and treatment with 0.4 Savofen with dexamethasone stress had the same performance, and there was no significant difference (p > 0.05). The negative control treatment and 0.2 Savofen treatment with dexamethasone stress also had the same performance (p > 0.05), but a significant difference was observed compared to the other treatments (p < 0.05). None of the blood traits, including blood glucose, triglyceride, cholesterol, HDL, LDL, VLDL, and glutamine, had significant differences (p > 0.05). Both aspartate aminotransferase and alanine aminotransferase enzymes were significantly different in the negative control treatment compared to the other treatments (p < 0.05). The two enzymes, superoxide dismutase and glutathione peroxidase, had significant differences in the positive control treatment compared to the other treatments (p < 0.05). In the malondialdehyde component, the positive control treatment of 0.2 Savofen with stress induction and dexamethasone had similar performance, but they were significantly different compared to the 0.4 Savofen treatment with stress induction and dexamethasone (p < 0.05). The total antioxidant capacity was also significantly different in the negative control treatment compared to the other treatments (p < 0.05). The components of corticosterone and triiodothyronine in the negative control treatment were significantly different from the other treatments (p < 0.05). On the other hand, there were no significant differences between the treatments in the tetraidothyronine component. The ratio of triiodothyronine to tetraiodothyronine was the same in all treatments and had a significant difference compared to the positive control treatment (p < 0.05).
Conclusion: In general, the 0.4 Savofen treatment under the stress conditions showed its positive performance during the stress conditions, and its performance was similar to the positive control treatment in most of the traits. Therefore, it can be concluded that this supplement can be used to improve stressful situations in rearing broiler chickens.
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