دوره 11، شماره 30 - ( زمستان 1399 )
جلد 11 شماره 30 صفحات 73-66 |
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AHMADI F, ZENDEHDEL M, BABAPOUR V, PANAHI N. (2020). Evaluating the Role of Corticotropin Receptors on Feed Intake Using Melanocortin Receptor Agonists in Neonatal Broilers. Res Anim Prod. 11(30), 66-73. doi:10.52547/rap.11.30.66
URL: http://rap.sanru.ac.ir/article-1-1068-fa.html
URL: http://rap.sanru.ac.ir/article-1-1068-fa.html
احمدی فریبا، زنده دل مرتضی، باباپور وهاب، پناهی نگار. بررسی نقش گیرندههای کورتیکوتروپینی بر مصرف غذا با استفاده از آگونیست گیرندههای M3 و M4 ملانوکورتینی در جوجه های گوشتی پژوهشهاي توليدات دامي 1399; 11 (30) :73-66 10.52547/rap.11.30.66
1- دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد علوم تحقیقات، تهران، ایران
2- دانشیار دانشکده دامپزشکی دانشگاه تهران، تهران. ایران
3- دانشکده دامپزشکی دانشگاه تهران، تهران. ایران
2- دانشیار دانشکده دامپزشکی دانشگاه تهران، تهران. ایران
3- دانشکده دامپزشکی دانشگاه تهران، تهران. ایران
چکیده: (2128 مشاهده)
شواهد به دست آمده از پژوهشهای حیوانی حاکی از نقش سیستم های کورتیکوتروپینی و ملانوکورتینی در مصرف خوراک دارد، اما ارتباط آنها تاکنون در پرندگان بررسی نشده است. در این پژوهش سه آزمایش با هدف بررسی گیرندههای کورتیکوتروپینی بر مصرف غذا با استفاده از آگونیست گیرنده های M3 و M4 ملانوکورتینی در جوجه های تازه از تخم درآمده انجام شد (هر آزمایش شامل چهار گروه و 11 جوجه در هر گروه بود). در آزمایش اول، جوجههای محروم از غذا به مدت سه ساعت، تزریقات داخل بطن مغزی (ICV) را به شکل زیر دریافت کردند: سالین، MTII (آگونیست گیرندههای MC3/MC4 (2/45، 4/9 و 9/8 پیکومول). در آزمایش دوم، سالین، MTII (9/8 پیکومول)، astressin-B (آنتاگونیست گیرنده های CRF1/ CRF2، 30 میکروگرم) و astressin-B + MTII تزریق شدند. در آزمایش سوم، جوجه ها با سالین، MTII (9/8 پیکومول)، astressin-2B (آنتاگونیست گیرنده های CRF2، 30 میکروگرم) و astressin-B + MTII تزریق شدند. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه گیری شد. با توجه به نتایج به دست آمده، کاهش وابسته به دوز بر مصرف غذا بعد از MTII دیده شد (0/05p<). تزریق داخل بطنی مغزی MTII (9/8 پیکومول) + astressin-2B موجب مهار هیپوفاژی ناشی از MTII شد (0/05p<). نتایج نشان دهنده این بود که هیپوفاژی ناشی از سیستم ملانوکورتینی از طریق گیرندههای CRF2 کورتیکوتروپینی در جوجه های گوشتی میانجیگری میشود.
فهرست منابع
1. Atsuchi, K., A. Asakawa, M. Ushikai, K. Ataka, M. Tsai and K. Koyama. 2010. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. Neuroreport, 21(15): 1008-1011. [DOI:10.1097/WNR.0b013e32833f7b96]
2. Bungo, T., K. Yahata, T. Izumi, K.I. Dodo, K. Yanagita and J.I. Shiraishi. 2008. Centrally administered tryptophan suppresses food intake in free fed chicks through the serotonergic system. The Journal of Poultry Science, 45(3): 215-219. [DOI:10.2141/jpsa.45.215]
3. Davis, J.L., D.T. Masuoka, L.K. Gerbrandt and A. Cherkin. 1979. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiology & Behavior, 22(4): 693-695. [DOI:10.1016/0031-9384(79)90233-6]
4. Dong, J., H. Xu, P.F. Wang, G.J. Cai, H.F. Song and C.C. Wang. 2013. Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice. PLoS One, 8(12): e83397. [DOI:10.1371/journal.pone.0083397]
5. Furuse, M., M. Matsumoto, N. Saito, K .Sugahara and S. Hasegawa. 1997. The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. European Journal of Pharmacology, 339(2-3): 211-213. [DOI:10.1016/S0014-2999(97)01391-5]
6. Guo, F.F., L. Xu, Sl. Gao, X. Sun, Z. Li and Y. Gong. 2015. The effects of nesfatin‐1 in the paraventricular nucleus on gastric motility and its potential regulation by the lateral hypothalamic area in rats. Journal of Neurochemistry, 132(3): 266-275. [DOI:10.1111/jnc.12973]
7. Heidarzadeh, H., M. Zendehdel, V. Babapour and H. Gilanpour. 2018. The effect of nesfatin-1 on food intake in neonatal chicks: role of CRF 1/CRF2 and H1/H3 receptors. Veterinary Research Communications, 42(1): 39-47. [DOI:10.1007/s11259-017-9706-9]
8. Iwasaki, Y., H. Nakabayashi, M. Kakei, H. Shimizu, M. Mori and T. Yada. 2009. Nesfatin-1 evokes Ca 2+ signaling in isolated vagal afferent neurons via Ca 2+ influx through N-type channels. Biochemical and Biophysical Research Communications, 390(3): 958-962. [DOI:10.1016/j.bbrc.2009.10.085]
9. Khazari ,B., M .Rezaei and M. kazemifard. 2019. The effect of different sources of insoluble fiber on performance, nutrient digestibility and blood parameters in broiler chicks. Rap, 10(24):1-9 [DOI:10.29252/rap.10.24.1]
10. Kohno, D., M. Nakata, Y. Maejima, H. Shimizu, U. Sedbazar and N. Yoshida. 2007. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology, 149(3): 1295-1301. [DOI:10.1210/en.2007-1276]
11. Kumar, K.G., G.M .Sutton, J.Z. Dong, P. Roubert, P. Plas and H.A. Halem. 2009. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R-and MC4R-deficient C57BL/6J mice. Peptides, 30(10): 1892-1900. [DOI:10.1016/j.peptides.2009.07.012]
12. Lam, D.D., M.J. Przydzial, S.H. Ridley, G.S. Yeo, J.J. Rochford and S.O'Rahilly. 2007. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology, 149(3): 1323-1328. [DOI:10.1210/en.2007-1321]
13. Lu, X.Y., G.S. Barsh, H. Akil and S.J. Watson. 2003. Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. Journal of Neuroscience, 23(21): 7863-7872. [DOI:10.1523/JNEUROSCI.23-21-07863.2003]
14. Mortazavi, S., R. Gonzalez, R. Ceddia and S. Unniappan. 2015. Long-term infusion of nesfatin-1 causes a sustained regulation of whole-body energy homeostasis of male Fischer 344 rats. Frontiers in Cell and Developmental Biology, 3: 22. [DOI:10.3389/fcell.2015.00022]
15. Novoseletsky, N., A. Nussinovitch and M. Friedman-Einat. 2011. Attenuation of food intake in chicks by an inverse agonist of cannabinoid receptor 1 administered by either injection or ingestion in hydrocolloid carriers. General and Comparative Endocrinology, 70 (3): 522-527. [DOI:10.1016/j.ygcen.2010.11.011]
16. Olanrewaju, H., J. Thaxton, W. Dozier, J. Purswell, W. Roush and S. Branton. 2006. A review of lighting programs for broiler production. International Journal of Poultry Science, 5(4): 301-308. [DOI:10.3923/ijps.2006.301.308]
17. Richard, D., Q. Lin and E. Timofeeva. 2002. The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. European Journal of Pharmacology, 440(2-3): 189-197. [DOI:10.1016/S0014-2999(02)01428-0]
18. Saito, E.S., H. Kaiya, T. Tachibana, S. Tomonaga, D.M. Denbow and K. Kangawa. 2005. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regulatory Peptides, 125(1-3): 201-208. [DOI:10.1016/j.regpep.2004.09.003]
19. Samadian F, M.J. Eskandari and M.R. Bahreini Behzadi. 2019. Preference of broiler chickens for feed color. Rap, 10(25): 1-7. [DOI:10.29252/rap.10.25.1]
20. Shousha, S., D. Kirat and T. Naso. 2015. Effect of central and peripheral nesfatin-1 on food intake in japanese quail. AASCIT Journal of Biology, 1(1): 1-9.
21. Silberman, Y. and D.G. Winder. 2013. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology, 70: 316-23. [DOI:10.1016/j.neuropharm.2013.02.014]
22. Stengel, A., M. Goebel, L. Wang, J. Rivier, P. Kobelt and H. Mönnikes. 2009. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology, 150(11): 4911-4919. [DOI:10.1210/en.2009-0578]
23. Stengel, A. and Y. Tache. 2013. Role of brain NUCB2/nesfatin-1 in the regulation of food intake. Current Pharmaceutical Design, 19(39): 6955-6959. [DOI:10.2174/138161281939131127125735]
24. Tachibana, T., K. Sugahara, A. Ohgushi, R. Ando and S.I .Kawakami, T .Yoshimatsu ., et al. 2001. Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks. Neuroscience Letters, 305(2): 131-134. [DOI:10.1016/S0304-3940(01)01827-4]
25. Yamada, H. and A.W. Bruijnzeel. 2011. Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats. Neuropharmacology, 60(2-3): 303-11. [DOI:10.1016/j.neuropharm.2010.09.013]
26. Atsuchi, K., A. Asakawa, M. Ushikai, K. Ataka, M. Tsai and K. Koyama. 2010. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. Neuroreport, 21(15): 1008-1011. [DOI:10.1097/WNR.0b013e32833f7b96]
27. Bungo, T., K. Yahata, T. Izumi, K.I. Dodo, K. Yanagita and J.I. Shiraishi. 2008. Centrally administered tryptophan suppresses food intake in free fed chicks through the serotonergic system. The Journal of Poultry Science, 45(3): 215-219. [DOI:10.2141/jpsa.45.215]
28. Davis, J.L., D.T. Masuoka, L.K. Gerbrandt and A. Cherkin. 1979. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiology & Behavior, 22(4): 693-695. [DOI:10.1016/0031-9384(79)90233-6]
29. Dong, J., H. Xu, P.F. Wang, G.J. Cai, H.F. Song and C.C. Wang. 2013. Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice. PLoS One, 8(12): e83397. [DOI:10.1371/journal.pone.0083397]
30. Furuse, M., M. Matsumoto, N. Saito, K .Sugahara and S. Hasegawa. 1997. The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. European Journal of Pharmacology, 339(2-3): 211-213. [DOI:10.1016/S0014-2999(97)01391-5]
31. Guo, F.F., L. Xu, Sl. Gao, X. Sun, Z. Li and Y. Gong. 2015. The effects of nesfatin‐1 in the paraventricular nucleus on gastric motility and its potential regulation by the lateral hypothalamic area in rats. Journal of Neurochemistry, 132(3): 266-275. [DOI:10.1111/jnc.12973]
32. Heidarzadeh, H., M. Zendehdel, V. Babapour and H. Gilanpour. 2018. The effect of nesfatin-1 on food intake in neonatal chicks: role of CRF 1/CRF2 and H1/H3 receptors. Veterinary Research Communications, 42(1): 39-47. [DOI:10.1007/s11259-017-9706-9]
33. Iwasaki, Y., H. Nakabayashi, M. Kakei, H. Shimizu, M. Mori and T. Yada. 2009. Nesfatin-1 evokes Ca 2+ signaling in isolated vagal afferent neurons via Ca 2+ influx through N-type channels. Biochemical and Biophysical Research Communications, 390(3): 958-962. [DOI:10.1016/j.bbrc.2009.10.085]
34. Khazari ,B., M .Rezaei and M. kazemifard. 2019. The effect of different sources of insoluble fiber on performance, nutrient digestibility and blood parameters in broiler chicks. Rap, 10(24):1-9 [DOI:10.29252/rap.10.24.1]
35. Kohno, D., M. Nakata, Y. Maejima, H. Shimizu, U. Sedbazar and N. Yoshida. 2007. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology, 149(3): 1295-1301. [DOI:10.1210/en.2007-1276]
36. Kumar, K.G., G.M .Sutton, J.Z. Dong, P. Roubert, P. Plas and H.A. Halem. 2009. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R-and MC4R-deficient C57BL/6J mice. Peptides, 30(10): 1892-1900. [DOI:10.1016/j.peptides.2009.07.012]
37. Lam, D.D., M.J. Przydzial, S.H. Ridley, G.S. Yeo, J.J. Rochford and S.O'Rahilly. 2007. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology, 149(3): 1323-1328. [DOI:10.1210/en.2007-1321]
38. Lu, X.Y., G.S. Barsh, H. Akil and S.J. Watson. 2003. Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. Journal of Neuroscience, 23(21): 7863-7872. [DOI:10.1523/JNEUROSCI.23-21-07863.2003]
39. Mortazavi, S., R. Gonzalez, R. Ceddia and S. Unniappan. 2015. Long-term infusion of nesfatin-1 causes a sustained regulation of whole-body energy homeostasis of male Fischer 344 rats. Frontiers in Cell and Developmental Biology, 3: 22. [DOI:10.3389/fcell.2015.00022]
40. Novoseletsky, N., A. Nussinovitch and M. Friedman-Einat. 2011. Attenuation of food intake in chicks by an inverse agonist of cannabinoid receptor 1 administered by either injection or ingestion in hydrocolloid carriers. General and Comparative Endocrinology, 70 (3): 522-527. [DOI:10.1016/j.ygcen.2010.11.011]
41. Olanrewaju, H., J. Thaxton, W. Dozier, J. Purswell, W. Roush and S. Branton. 2006. A review of lighting programs for broiler production. International Journal of Poultry Science, 5(4): 301-308. [DOI:10.3923/ijps.2006.301.308]
42. Richard, D., Q. Lin and E. Timofeeva. 2002. The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. European Journal of Pharmacology, 440(2-3): 189-197. [DOI:10.1016/S0014-2999(02)01428-0]
43. Saito, E.S., H. Kaiya, T. Tachibana, S. Tomonaga, D.M. Denbow and K. Kangawa. 2005. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regulatory Peptides, 125(1-3): 201-208. [DOI:10.1016/j.regpep.2004.09.003]
44. Samadian F, M.J. Eskandari and M.R. Bahreini Behzadi. 2019. Preference of broiler chickens for feed color. Rap, 10(25): 1-7. [DOI:10.29252/rap.10.25.1]
45. Shousha, S., D. Kirat and T. Naso. 2015. Effect of central and peripheral nesfatin-1 on food intake in japanese quail. AASCIT Journal of Biology, 1(1): 1-9.
46. Silberman, Y. and D.G. Winder. 2013. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology, 70: 316-23. [DOI:10.1016/j.neuropharm.2013.02.014]
47. Stengel, A., M. Goebel, L. Wang, J. Rivier, P. Kobelt and H. Mönnikes. 2009. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology, 150(11): 4911-4919. [DOI:10.1210/en.2009-0578]
48. Stengel, A. and Y. Tache. 2013. Role of brain NUCB2/nesfatin-1 in the regulation of food intake. Current Pharmaceutical Design, 19(39): 6955-6959. [DOI:10.2174/138161281939131127125735]
49. Tachibana, T., K. Sugahara, A. Ohgushi, R. Ando and S.I .Kawakami, T .Yoshimatsu ., et al. 2001. Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks. Neuroscience Letters, 305(2): 131-134. [DOI:10.1016/S0304-3940(01)01827-4]
50. Yamada, H. and A.W. Bruijnzeel. 2011. Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats. Neuropharmacology, 60(2-3): 303-11. [DOI:10.1016/j.neuropharm.2010.09.013]
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