Volume 8, Issue 15 (6-2017)                   rap 2017, 8(15): 42-48 | Back to browse issues page

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Amelioration of Experimental B1 Aflatoxicosis in Japanese Quails by Yolk Derived Specific Antibody . rap. 2017; 8 (15) :42-48
URL: http://rap.sanru.ac.ir/article-1-750-en.html
Abstract:   (913 Views)

Two experiments were carried out to determine the potential of oral yolk derived specific antibody against aflatoxin B1 in Japanese quails. In the first experiment egg yolk derived antibody against aflatoxin B1 was produced in layer quails. The potential of aflatoxin absorbent of the eggs from immunized and non-immunized layers was assayed in vitro. Egg yolk extracts derived from aflatoxin-BSA conjugate immunized layers absorbed more aflatoxin B1 compared to that of non-immunized birds in concentrations over 24 g/l (P <0.05). In the second experiment 120, one-d-old quails were randomly attributed to four experimental groups with five replications of six chicks. The experimental groups consisting: 1- negative control- fed uncontaminated feed. 2- Positive control- fed aflatoxin B1 (2 mg/kg) contaminated feed.
3- AFB1+SY- fed contaminated feed and 4 g/l yolk extract form immunized layers in drinking water. 4- AFB1+NY- fed contaminated feed and 4 g/l yolk extract form non-immunized layers in drinking water. Feeding aflatoxin without yolk extract lowered serum concentrations of total protein, albumin, HDL, triglyceride, cholesterol and glucose. Oral yolk extracts restored the aflatoxicosis-induced alteration of serum metabolits to the normal levels similar to negative control. The yolk extract derived from immunized layers was more efficient compared to that of non-immunized birds. Aflatoxicosis diminished the studied cellular and humoral immune responses (P < 0.05), while oral yolk extracts boosts the immune responses to a level comparable to negative control.

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Type of Study: Research | Subject: Special
Received: 2017/06/17 | Revised: 2017/08/27 | Accepted: 2017/06/17 | Published: 2017/06/17

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